• FIGHTING THE SPREAD OF
      INFECTIOUS DISEASE WITH
      DDN WOS

PUBLIC HEALTH ENGLAND

As an executive agency of the Department of Health in the United Kingdom, Public Health England’s (PHE) mission is to protect and improve the nation’s health while reducing health inequalities. PHE employs more than 5,500 people, most of whom are scientists and public health professionals focused on making the public healthier through research, analysis and guidance to government entities as well as supporting action by local government, the National Health Service and other organizations.

PHE is pioneering a next-generation, centralized sequencing service to generate and analyze the near-complete genetic code of pathogenic bacteria and viruses. In order to support these advanced sequenced services, PHE required a storage solution that could seamlessly scale across all tiers.

Read their case study to learn how high-performance DDN® storage has helped PHE:

  • Achieve 16x faster processing of genomic data
  • Leverage massive parallel I/O capabilities to turn around results in hours instead of days
  • Support the heavy I/O and data analysis requirements of the organization, where streamlining access to data and accelerating time to results is critical

 

CHALLENGES

  • A robust IT infrastructure with large-scale, high-throughput performance is essential to supporting PHE’s new centralized sequencing service
  • Requirement to turnaround results in hours instead of days to support the need to rapidly and effectively characterize pathogens
  • To meet stringent sequencing and analysis demands, a complete data management lifecycle solution with multiple tiers of storage to deliver parallel I/O data throughput, a near-line archive and a private cloud for geographically distributed data access

SOLUTION

  • A high-performance computing cluster for variant calling and de novo assembly paired with EXAScaler SFA high-performance parallel storage solution. WOS and iRODs for collaboration between PHE sites and a near-line archive for re-analysis.

BUSINESS BENEFITS

    • The ability to quickly and effectively characterize major pathogens by determining mutations and gene variants will prove pivotal in reducing major outbreaks and epidemics
    • DDN is helping PHE fulfill its vision of speeding the identification and typing of bacteria and viruses

 


TECHNICAL BENEFITS

  • Highly parallel I/O enables PHE to process and analyze hundreds of DNA samples simultaneously
  • PHE gains seamless long-term data access through WOS active archive and offsite backup and data lifecycle management using iRODS
  • PHE is better positioned to meet the stringent demands of its bioinformatics analysis workflows, using best practice tools for variant analysis, mutation detection and de novo assembly